Brain fog is often a signaling problem, not a willpower one. Clinically studied psychobiotic strains restore serotonin and dopamine communication via the gut-brain axis, while B. breve BBr60 reduces the neuroinflammation that dulls cognitive sharpness.
Your Brain Will Feel It
Cognitive Support Rooted in the Gut-Brain Axis and Mitochondria Energy Production
From Our Community
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NEUROBIOME™
A better start to my day.
I worked this into my morning routine and it felt easy to keep up. First my digestion evened out, then a week or so later the focus and calm kicked in. Didn't expect the two to be linked, but here we are.
Sarah K. Verified customer -
NEUROBIOME™
It helped my routine feel more controlled.
I wanted something that felt more sustainable than another quick fix. Neurobiome fit naturally into my day and helped me feel more aware and focused.
Nico M. Verified customer -
NEUROBIOME™
Simple enough to actually keep using.
What I like most is how easy it is. No complicated steps. Just two capsules that take care of both my gut and my brain.
Emma L. Verified customer -
NEUROBIOME™
Calm but switched on.
I get anxious focus — locked in but kind of wired. This gives me the focus without the wired part. Steadier under pressure, especially on high-stakes days. Not a stimulant, which is exactly what I wanted.
James R. Verified customer -
NEUROBIOME™
Skeptical gut-health guy, converted.
I've tried Seed, AG1, a drawer full of stuff. This is the first one where I felt a difference in how I think, not just how I digest. The strain list actually has research behind it, which is why I tried it. Glad I did.
Daniel V. Verified customer
92%
felt noticeably clearer thinking and smoother focus within the first 2–3 weeks of daily use.
89%
experienced more stable, sustained daytime energy without relying on caffeine or stimulants.
88%
reported a calmer, more balanced mood and improved stress resilience after consistent use.
84%
experienced better gut comfort and smoother digestive well-being.
*Based on consumer study (n=89) after 4 weeks of daily use
HPMC Enteric Encapsulation Technology
Engineered to Maximize Bioavailability
1. Enteric-Protected Delivery
The enteric capsule resists dissolution in stomach acid, passing through intact to the lower intestine — where live probiotic strains, tributyrin, and sensitive bioactives are biologically active. Standard capsules break down in the stomach, degrading these compounds before they reach their target site.
2. Multi-Pathway Formula, One Capsule
Psychobiotic strains, mitochondrial cofactors, L-theanine, tributyrin, inulin, B-vitamins, and D3 — precision-dosed as a single powder blend.
No separate pills, no redundant supplements, no compromise on formulation depth.
2. Multi-Pathway Formula, One Capsule
Psychobiotic strains, mitochondrial cofactors, L-theanine, tributyrin, inulin, B-vitamins, and D3 — precision-dosed as a single powder blend.
No separate pills, no redundant supplements, no compromise on formulation depth.
3. Enhanced Bioavailability & Probiotic Viability
Enteric protection significantly improves the survival rate of live probiotic strains through gastric transit compared to standard capsules.
Neurobiome™ reaches both gut and neural pathways with precision, offering clear, stimulant-free energy without supplement overload
Research-backed Ingredients Optimized for Cognitive Performance
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Neurobiome™
Four cognition-focused probiotic strains that reconnect your gut and mind
Mood · Focus · Stress Resilience
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Tributyrin
Bioavailable butyrate that feeds your gut lining and calms inflammation
Gut Barrier · Cellular Fuel · Clarity
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CoQ10 + PQQ
Works synergistically to support mitochondrial function and biogenesis
Cellular Energy · Mitochondrial Renewal · Steady Stamina
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L-Theanine
Amino acid naturally found in green tea that promotes calm alertness without sedation
Calm Focus · Alertness · Steady Attention
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Vitamin B Complex + D3
Foundational nutrients your brain needs to make dopamine and serotonin
Neurotransmitter Support · Mood Balance · Mental Clarity
Neurobiome™
Science
- Supports gut–brain axis signaling and neurotransmitter modulation
- Helps regulate stress response and cortisol levels
- Supports emotional resilience and mood balance
- Promotes intestinal barrier integrity and immune balance
- Prebiotic inulin enhances SCFA production and probiotic viability
Clinical Studies
- Chong H.X. et al. (2019).Lactobacillus plantarum DR7 alleviates stress and anxiety in adults: A randomized, double-blind, placebo-controlled study. Beneficial Microbes.
- Liu G. et al. (2020).Lactobacillus plantarum DR7 modulates bowel function, gut microbiota and neurotransmitter pathways in stressed adults. Microorganisms.
- Zaydi A.I. et al. (2020).Lactobacillus plantarum DR7 improved brain health in aging rats via the serotonin, inflammatory and apoptosis pathways. Beneficial Microbes.
- Patterson E. et al. (2020).Lacticaseibacillus paracasei Lpc-37 improves psychological and physiological markers of stress and anxiety in healthy adults: A randomized, double-blind, placebo-controlled trial. Neurobiology of Stress.
- Mäkelä et al. (2023). fficacy and safety of Lacticaseibacillus paracasei Lpc-37® in students facing examination stress. Brain, Behavior, & Immunity–Health (The ChillEx Study)
- Li M. et al. (2025). A preliminary exploration of establishing a mice model for hypoxic training and determining the optimal time point for peak performance after altitude exposure. Scientific Reports.
- Bai et al. (2025). The impact of Bifidobacterium breve BBr60 on metabolic and gastrointestinal health in healthy adults. Journal of Human Nutrition and Dietetics.
Tributyrin
Science
- Supports intestinal permeability and tight junction integrity
- Enhances mitochondrial function and cellular energy
- Modulates inflammatory pathways
- Supports memory, synaptic plasticity, and cognitive resilience
- Promotes healthy microbiome signaling
Clinical Studies
- Dosz et al. (2025) — Multi-center RCT"Tributyrin supplementation improves gut barrier function and reduces behavioral markers of stress in adults"
- Bourassa et al. (2016) — Neurochemical Research "Butyrate, neuroepigenetics and the gut microbiome: can a high fiber diet improve brain health?"
- Barve et al. (2024) — Nutritional Neuroscience "Tributyrin supplementation and neuroprotection: preclinical and early human data"
- Postal et al. / Tributyrin IBD & Gut Barrier (2021)"Tributyrin as a colonocyte fuel and gut barrier protector"
CoQ10 + PQQ
Science
- Supports ATP production and cellular energy output
- Promotes mitochondrial biogenesis (via PQQ signaling pathways)
- Supports cognitive clarity and mental energy
- Helps reduce oxidative stress
- May support cardiovascular and neuronal health
Clinical Studies
- Ikemoto et al. (2024) — Journal of Medical Investigation."The effects of pyrroloquinoline quinone disodium salt on brain function and physiological processes"
- Ohwada et al. (2008) — Journal of Clinical Biochemistry and Nutrition. "Pyrroloquinoline Quinone (PQQ) Prevents Cognitive Deficit Caused by Oxidative Stress in Rats"
- Itoh et al. (2016) — Advances in Experimental Medicine and Biology. "Effect of Pyrroloquinoline Quinone Disodium Salt (BioPQQ™) on Cognitive Functions"
- Ikemoto et al. (2022) — Food & Function. "Pyrroloquinoline quinone disodium salt improves brain function in both younger and older adults"
- Zozina et al. (2018) — Current Cardiology Reviews. "Coenzyme Q10 in cardiovascular and metabolic diseases: current state of the problem"
L-Theanine
Science
- Promotes calm focus and alpha wave activity
- Helps reduce stress-induced cortisol response
- Supports attention and cognitive performance
- Enhances relaxation without drowsiness
- May improve sleep quality in stressed individuals
Clinical Studies
- Hidese et al. (2019) — Nutrients."Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial"
- Kimura et al. (2007) — Biological Psychology. "L-Theanine reduces psychological and physiological stress responses"
- Lopes Sakamoto et al. (2019) — Nutrients. "The Effects of Dietary Supplementation with L-Theanine on Sleep Quality in Young Adults"
- Systematic Review — Lardner (2014) — Nutritional Neuroscience. "The effects of dietary and supplemental theanine on human physiology and behaviour"
Vitamin B Complex + D3
Science
- Supports neurotransmitter synthesis (serotonin, dopamine, GABA)
- Contributes to methylation and homocysteine regulation
- Supports cognitive performance and mental energy
- Helps regulate neuroimmune signaling and inflammatory balance
- Supports mood stability and stress resilience
- Contributes to mitochondrial ATP production
Clinical Studies
- Smith et al. (2010) — VITACOG — International Journal of Geriatric Psychiatry."Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment"
- de Jager et al. (2012) — International Journal of Neuropsychopharmacology."Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment"
- Mikola et al. (2023) — Translational Psychiatry."The effect of vitamin D supplementation on depressive symptoms in adults: a systematic review and meta-analysis"
- Ghaemi et al. (2024) — Nutrients. "Dose-response relationship between vitamin D supplementation and depression outcomes"
- Naeini et al. (2025) — Journal of Affective Disorders."Vitamin D supplementation increases BDNF and improves cognitive function"
- Skarupski et al. (2010) — American Journal of Clinical Nutrition"Longitudinal association of vitamin B-6, folate, and vitamin B-12 with depressive symptoms among older adults"
- Kennedy et al. (2016) — Nutrients"B Vitamins and the Brain: Mechanisms, Dose and Efficacy — A Review"
Your Neurobiome™ Journey
How support may build over time
Every body responds differently. Here's what a typical Neurobiome™ journey may look like with consistent use.
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Days 1 to 7Smoother energy begins
Early changes may include calmer focus, smoother energy, and less of the usual afternoon crash.
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Days 7 to 14Clearer thinking
Stress resilience may improve, with clearer thinking and steadier attention through demanding days.
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Weeks 2–4Mood stability builds
Mood stability and cognitive consistency may strengthen as gut-brain signaling rebalances.
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Weeks 4–8 and beyondGut-brain support deepens
Deeper gut-brain support and cellular benefits as the microbiome shifts with consistent daily use.
Not All Brain Supplements are Built Alike
Brain science has moved on, but so many brands have missed the memo: optimal brain function relies on both neural metabolism and gut-brain axis support. Neurobiome™ delivers both.
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NEUROBIOME™
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Standard nootropics
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Generic Probiotics
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Clinically Studied and Strain-Specific Probiotics
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Gut-Brain Axis Support (Psychobiotics)
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Mitochondrial Energy Support (CoQ10 + PQQ)
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Postbiotic / Butyrate Signaling (Tributyrin)
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rare
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Neurotransmitter Cofactors (B-Vitamins, D3)
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Stimulant-Free Cognitive Performance
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Enteric-Protected Delivery
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Multi-Pathway Formula Depth
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Designed Sustainably. Delivered Monthly.
Our refill system is engineered to preserve the integrity of your Archemi formula while minimizing waste and respecting the planet we share.
Welcome Kit
First shipment- Free refillable glass bottle
- Free travel vial
- 30-day (90-day) supply - monthly (quarterly) subscription
Refills
Subsequent shipment- Monthly or quarterly refills
Risk-Free Promise
Feel it, or get your money back.
90DAY
GUARANTEE · QUARTERLY PLAN
Three full months to experience the difference. If you don't feel it — complete refund, no questions.
- 90-DAY GUARANTEE (QUARTERLY)
- 30-DAY GUARANTEE (MONTHLY)
- CANCEL, PAUSE & RESCHEDULE ANYTIME
- THIRD-PARTY TESTED
Start with confidence — get clear on the details.
Neurobiome™ is a daily Gut–Brain–Cellular Probiotics+ formula designed to support focus, mood, stress resilience, and long-term cognitive health - without caffeine or stimulants.
It combines four clinically studied probiotics, calm-focus nootropics (L-Theanine), a mitochondrial biogenesis stack (CoQ10 and PQQ), active B-vitamins, Vitamin D3, and Tributyrin for short-chain fatty acid support.
Neurobiome™ supports mental performance through five interconnected biological systems — linking the gut, brain, and cellular energy pathways.
1. Gut–Brain Axis Regulation
Four clinically studied probiotic strains support bidirectional communication between the gut and brain by influencing neuroactive compounds, vagus nerve signaling, and the body’s stress response system (HPA axis).
A balanced microbiome helps promote mood stability, stress resilience, and mental clarity.
2. Mitochondrial Energy & Renewal
CoQ10 and PQQ support efficient ATP production and mitochondrial renewal pathways — helping sustain clean, steady cognitive energy without stimulants.
3. Calm–Focus Modulation
L-Theanine supports alpha brainwave activity and helps balance excitatory signaling, promoting relaxed alertness, improved attention, and reduced mental tension — without sedation or stimulants.
4. Gut & Cellular Integrity
Tributyrin delivers bioavailable butyrate to support gut barrier strength, inflammatory balance, and cellular resilience.
5. Neurotransmitter Support
Active B-vitamins and Vitamin D3 provide essential cofactors for dopamine, serotonin, and overall cognitive processing.
The result: integrated support for cognitive performance, emotional regulation, and long-term brain resilience — powered through the gut–brain–cellular axis.
Most nootropics rely on caffeine or synthetic stimulants. Neurobiome™ is stimulant-free and works on the root biology of cognition:
- gut–brain axis regulation
- mitochondrial energy
- neurotransmitter synthesis
- cellular resilience (SCFAs)
- mood and stress pathways
It’s a biotech-designed cognitive longevity formula, not a quick-fix stimulant.
Regular probiotics mostly target digestion. Neurobiome™ targets cognition, stress resilience, and mental clarity using:
- L. plantarum Lp05® — supports cognitive performance and mood pathways
- L. paracasei Lpc-37® — supports stress response and HPA-axis modulation
- B. lactis BLa80® — supports gut barrier integrity and immune balance
- B. breve BBr60® — associated with metabolic and gut-brain signaling support
- Tributyrin — short-chain fatty acid for gut barrier and neuroinflammatory balance
- 56B CFU stability
- Delivery designed to increase viability and reduce ingredient conflict through enteric encapsulation
This is a cognitive-grade probiotic — not a typical gut supplement.
Most people take Neurobiome™ for:
- clearer thinking
- improved focus
- calmer mood
- better stress resilience
- consistent daily energy
- less reliance on caffeine
- gut balance and comfort
- long-term cognitive health
Every body is unique, but typical timelines:
- Days 1–7: calmer focus, smoother energy, less crash
- Days 7–14: improved stress resilience, clearer thinking
- Weeks 2–4: stronger mood stability, cognitive consistency
- Weeks 4–8: deeper gut-brain support and cellular benefits
Consistency is key — Neurobiome™ is a daily optimization formula, not a quick-fix stimulant.
Yes — it’s designed for daily optimization. Cognitive benefits are cumulative.
Yes. We only use clinically studied probiotic strains with established evidence on gut-brain benefits.
Take 2 capsules once daily with or after food in the morning. Individual responses may vary — you may start with 2 capsules and adjust as needed. Reduce to 1 capsule if you prefer a lighter effect, or take up to 3 capsules for additional support.
Yes — the capsule and all ingredients are vegan-friendly.
No — the strains and formulation are shelf-stable. Store in a cool, dry place away from direct sunlight.