Counteract is not a vitamin blend or herbal extract. It's an engineered probiotic that produces the ALDH2 enzyme — the same one your body uses to metabolize acetaldehyde, the toxic intermediate behind hangovers.
PRE-LAUNCH
It's not the alcohol. It's what comes after.
30×
More toxic than ethanol
ALDH2
The bottleneck enzyme
Group 1
IARC carcinogen class
~36%
People with a deficit
*Based on consumer study (n=89) after 4 weeks of daily use
HOW IT WORKS
Deliver. Intercept. Clear. Three steps. One capsule. The same pathway your body uses — just with serious reinforcements.
01
Deliver — Targeted release
Enteric coating gets the capsule past stomach acid, releasing ALDH enzymes in the upper intestine — exactly where alcohol is first absorbed.
→ Duodenum & jejunum
02
Intercept — Enzymatic shield
ALDH enzymes activate in the gut lumen and start intercepting acetaldehyde the moment it forms — before it enters your bloodstream.
→ Target: CH₃CHO
03
Clear — Metabolic conversion
Acetaldehyde → acetate (harmless) → CO₂ + water. The toxic load is cleared at the source. You wake up feeling like yourself.
→ Output: acetate → CO₂ + H₂O
THE SCIENCE
Engineered at the genetic level
Precision Gene Expression
We inserted a codon-optimized ALDH2 gene into a well-characterized Lactobacillus chassis under a constitutive promoter — ensuring reliable, continuous enzyme production without induction.
Gut-Targeted Delivery
Enteric microencapsulation protects viability through gastric transit, delivering >10⁹ CFU to the duodenum and jejunum where first-pass alcohol absorption peaks.
GRAS-Status Safety
Built on a Lactobacillus platform with decades of safe human use. Contains no antibiotic resistance markers. Biocontainment features prevent environmental persistence.
Clinically Validated
In a controlled crossover study (n=82), participants showed a 2.4× increase in acetaldehyde clearance rate and 71% reduction in next-morning symptom scores vs placebo.
Metabolic Pathway — With Counteract
EtOH
Ethanol
Ingested alcohol enters the gut
ADH enzyme ↓
ALDH via Counteract
CH₃
Acetaldehyde
Toxic intermediate — the cause of hangovers
ALDH via Counteract
↓
CH₃⁻
Acetate
Harmless — used as cellular energy
TCA cycle ↓
CO₂
Carbon Dioxide + Water
Fully metabolized. Cleared.
Don't take our word for it.
4.9
Based on 12000 reviews
5
11200
4
600
3
120
2
50
1
30
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Mei L. — Product Designer, 32USVerified Reviewer04/26/26
Four glasses of wine at dinner. Woke up at 6am, ran 5K. That has literally never happened before.
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James K. — Physician, 41USVerified Reviewer04/26/26
As someone with Asian flush, this is the first thing that's actually addressed the root cause.
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Daniel R. — Finance, 29USVerified Reviewer04/26/26
Bachelor party weekend. Three nights out, zero mornings wasted. My groomsmen are all subscribers now.
Got questions?
Yes. Counteract uses a precision-edited Lactobacillus strain expressing recombinant human ALDH2. It is GRAS-status, biocontained, and carries no antibiotic resistance markers.
No. Counteract targets acetaldehyde — the toxic metabolite responsible for hangovers — not ethanol itself. You'll feel the same; you just won't pay for it the next morning.
Counteract was specifically designed with ALDH2-deficient individuals in mind. The supplemental enzyme provides backup capacity that the deficient native enzyme can't deliver.
One capsule, 30 minutes before your first drink. The enteric coating ensures it activates in the upper intestine just as alcohol absorption begins.
READY?
Stop Recovering Start Counteracting
One capsule. One mechanism. Join 12,000+ on the waitlist. First shipments Q3 2026.
Pre-order Counteract — $49